博士生刘晓霞的论文被Journal of Theoretical Biology录用
新闻来源:IR实验室       发布时间:2017/12/4 9:41:20

2017123日,接到编辑部通知,博士生刘晓霞的论文“The impact of protein interaction networks' characteristics on computational complex detection methods”被Journal of Theoretical Biology录用,该期刊是影响因子为2.113SCI期刊。

下面是论文的摘要部分:

Protein complexes of physically interacting proteins play an important role in organizing various biological processes in the cell. Therefore, correctly identifying complexes is useful for deciphering the cellular mechanisms underlying many biological processes. Since the existing high-throughput techniques have produced a large amount of protein interactions, computational methods are useful complements to the experimental methods for detecting protein complexes. In this paper, we analyze six protein interaction networks widely used for protein complex detection, and compare the performance of six classic computational methods on them in order to find the impacts of network characteristics on the performances of these complex detection methods. Furthermore, we change topological characteristics of six protein interaction networks, and verify the findings by testing performances of six methods on new ones. We hope our study will not only help recognize the relations between characteristics of protein interaction networks and computational complex detection methods, but also provide valuable insight to improve the performance in protein complex detection area.